Sharp Plasmacluster Technology Reduces Airborne Coronavirus

Plasmacluster Technology Demonstrates Effectiveness in Reducing Airborne Novel Coronavirus (SARS-CoV-2) *1, a World First*2

In a world first, Sharp Corporation developed a device equipped with Plasmacluster technology, which exposed an airborne novel coronavirus (SARS-CoV-2) to Plasmacluster ions for approximately 30 seconds*3, and demonstrated that the virus infectious titer*4 was reduced more than 90%. This achievement was accomplished in collaboration with Professor Jiro Yasuda of the National Research Center for the Control and Prevention of Infectious Diseases/Institute of Tropical Medicine, Nagasaki University, Professor Asuka Nanbo (a Board member of the Japanese Society for Virology) of the same institution, and Professor Hironori Yoshiyama of the Department of Microbiology, Shimane University Faculty of Medicine (also a Board member of the Japanese Society for Virology), and in cooperation with Nagasaki University, an internationally respected authority on infectious disease research.

In December 2019, an outbreak of “Coronavirus disease 2019 (COVID-19)” caused by a novel coronavirus (SARS-CoV-2) was reported, and by August 2020, more than 25 million people have been infected with SARS-CoV-2 and more than 840,000 individuals died of this infectious disease in a world*5. This outbreak represents an urgent problem facing society, and demands that immediate countermeasures be taken across a wide range of fields.

In 2004, Sharp demonstrated the effectiveness of Plasmacluster technology against feline (cat) coronavirus, a member of the Coronaviridae family*6. In the following year, 2005, Sharp also demonstrated its effectiveness against the original SARS coronavirus*7 (SARS-CoV), which caused the outbreak (2002-2003) and genetically similar to the novel coronavirus (SARS-CoV-2). Now, Sharp has demonstrated its effectiveness against SARS-CoV-2 in airbornedroplets.

Since 2000, Sharp has promoted academic marketing*8 to demonstrate the effectiveness of Plasmacluster technology, working in collaboration with independent third-party research organizations around the world. Thus far, numerous independent research organizations have proven its clinical efficacy in suppressing the activity of harmful substances including new pandemic influenza viruses, drug-resistant bacteria, and mite allergens, as well as in reducing bronchial inflammation levels*9 in children with asthma. At the same time, the safety of Plasmacluster ions has also been confirmed*10. Sharp will continue to contribute to society by conducting a wide range of studies demonstrating the effectiveness of Plasmacluster technology.

Comments from Dr. Jiro Yasuda, Professor, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University

Disinfectants such as alcohol and detergents (surfactants) are well-known to be effective to reduce the risk of the virus on materials, however, for infection via aerosols (microdroplets), there are few effective countermeasures such as a mask.

Here, effective inactivation of SARS-CoV-2 in airborne droplets by Plasmacluster technology was demonstrated.- It would be expected that it is useful to reduce the risk of infection in real spaces including office, home, medical facilities and vehicles.

*1 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): The strain of coronavirus that causes coronavirus disease 2019 (COVID-19).

*2 In ion-emission air purification technologies (as of September 7, 2020; based on Sharp research).

*3 Calculated by dividing the test space volume by the flow recovery rate, assuming that the aerosol containing the virus is passing through the space at a constant speed.

*4 Number of infectious virus

*5 Based on data from Johns Hopkins University (as of August 31, 2020).

*6 Announced on July 27, 2004.

*7 Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group. bioRxiv doi 10.1101/2020.02.07.937862 (February 11, 2020).

*8 A marketing method to promote commercialization of products based on verification of scientific data on the effectiveness of a technology in collaboration with leading-edge academic research institutions.

*9 Announced on September 18, 2014.

*10 Tests conducted by LSI Medience Corporation (inhalation toxicity, eye/skin irritation/corrosion, and teratogenicity tests, plus a two-generation reproduction toxicity study)

Plasmacluster and the Plasmacluster logos are registered trademarks of Sharp Corporation.

■ Overview of Verification Test

Testing organization: National Research Center for the Control and Prevention of Infectious Diseases (CCPID)/Institute of Tropical Medicine, Nagasaki University

Verification test apparatus: Virus testing device equipped with Plasmacluster technology

Plasmacluster ion concentration: Approx. 10 million/cm3 (in the vicinity of the Plasmacluster ion generator)

Test space volume: Approx. 3 liters

Control study: Comparison using the device described above without Plasmacluster ion generation

Validation virus: Novel Coronavirus (SARS-CoV-2)

Test method

1) Pass the aerosolized virus through the test devise from the generator.

2) Recover the aerosolized virus after exposure to Plasmacluster ions.

3) Calculate the infectious virus titer of the recovered virus solution by a plaque assay*.

* A standard assay to evaluate the number of infectious virus in the sample.

■ Results

Table 1 Effect of Plasmacluster ions on infectious titer of novel coronavirus (SARS-CoV-2) suspended in air

Without Plasmacluster ions With Plasmacluster ions Reduction
Infectious virus titer (number of plaque) 1.76 x 104 1.54 x 103 91.3%

About Plasmacluster Technology

Positively charged ions (H+ (H2O)m) and negatively charged ions (O2– (H2O)n) are released into the air simultaneously, and the positive and negative ions instantaneously bond on the surface of airborne bacteria, fungi, viruses, allergens, and the like, becoming OH (hydroxyl) radicals which have very high oxidizing power. This is a unique air purification technology that works to suppress the activity of bacteria, etc., by breaking down proteins on their surface by a chemical reaction.

Mechanism for Inhibiting the Activity of Airborne Bacteria

Comparison of Oxidizing Power

The OH– (hydroxyl) radical has the strongest oxidizing power among active oxygen species

Active Oxygen Species Chemical Formula Standard Oxidation Potential [V]
OH– (hydroxyl) radical OH 2.81
Oxygen atom O 2.42
Ozone O3 2.07
Hydrogen peroxide H2O2 1.78
Hydroperoxyl radical OOH 1.70
Oxygen molecule O2 1.23

■ Research Institutes That Provided Data for Sharp’s Academic Marketing

Target Testing and Verification Organization
Efficacy proven in clinical trials Graduate School of Medicine, University of Tokyo / Public Health Research Foundation
Faculty of Science and Engineering, Chuo University / Clinical Research Support Center, University Hospital, University of Tokyo
Animal Clinical Research Foundation
Soiken Inc.
School of Bioscience and Biotechnology, Tokyo University of Technology
National Trust Co., Ltd. / HARG Treatment Center
National Center of Tuberculosis and Lung Diseases, Georgia
Dentsu ScienceJam Inc.
Littlesoftware Inc.
National Institute of Fitness and Sports in Kanoya
Viruses Kitasato Research Center of Environmental Sciences
Seoul National University
Shanghai Municipal Center for Disease Control and Prevention, China
Kitasato Institute Medical Center Hospital
Retroscreen Virology, Ltd., UK
Shokukanken Inc.
University of Indonesia
Hanoi College of Technology, Vietnam National University, Vietnam
Institut Pasteur, Ho Chi Minh City, Vietnam
National Research Center for the Control and Prevention of

Infectious Diseases/Institute of Tropical Medicine,

Nagasaki University

Allergens Graduate School of Advanced Sciences of Matter, Hiroshima University
Department of Biochemistry and Molecular Pathology, Graduate School of Medicine, Osaka City University
Fungi Ishikawa Health Service Association
University of Lübeck, Germany
Professor Gerhard Artmann, Aachen University of Applied Sciences, Germany
Japan Food Research Laboratories
Shokukanken Inc.
Shanghai Municipal Center for Disease Control and Prevention, China
Biostir Inc.
Medical Mycology Research Center, Chiba University
Bacteria Ishikawa Health Service Association
Shanghai Municipal Center for Disease Control and Prevention, China
Kitasato Research Center of Environmental Sciences
Kitasato Institute Medical Center Hospital
Dr. Melvin W. First, Professor Emeritus, Harvard School of Public Health, US
Animal Clinical Research Foundation
University of Lübeck, Germany
Professor Gerhard Artmann, Aachen University of Applied Sciences, Germany
Japan Food Research Laboratories
Shokukanken Inc.
Chest Disease Institute, Thailand
Biostir Inc.
Odors, pet smells Boken Quality Evaluation Institute
Skin beautifying effects School of Bioscience and Biotechnology, Tokyo University of Technology
Hair beautifying effects Saticine Medical Co., Ltd.
C.T.C Japan Ltd.
Plant Facility of Agriculture, Shizuoka University
Hazardous chemical substances Sumika Chemical Analysis Service Ltd.
Indian Institutes of Technology
Working mechanism of inhibitory effects on viruses, fungi, and bacteria Professor Gerhard Artmann, Aachen University of Applied Sciences, Germany
Working mechanism of inhibitory effects on allergens Graduate School of Advanced Sciences of Matter, Hiroshima University
Working mechanism of skin moisturizing (water molecule coating) effect Research Institute of Electrical Communication, Tohoku University

SOURCE Sharp Electronics

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